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The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging.

Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China. Department of Cardiac Surgery, Fuwai Hospital, Beijing, People's Republic of China. Fuwai Yunnan Cardiovascular Hospital, Kunming, Yunnan, People's Republic of China. University of Texas, Houston, TX, USA. Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China. Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China. yangxin_li@yahoo.com.

Advances in experimental medicine and biology. 2018;:347-368
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Abstract

Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.

Methodological quality

Publication Type : Review

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MeSH terms : Aging ; Muscle, Skeletal